(1) COC achieves fertility control by inhibiting ovulation, changing cervical mucus properties, altering endometrial morphology and function, and changing fallopian tube function, and other multi-linked effects. (2) COC has the advantages of high efficiency, simplicity and reversibility. When used correctly, the contraceptive efficiency of COC can reach more than 99%. (3) COC is suitable for routine contraception in healthy women of reproductive age, but contraindications to COC and risk factors need to be excluded at the time of use. Studies have shown that the use of contraceptive drugs is effective in avoiding maternal deaths and would reduce maternal mortality by 29% annually if contraceptive needs were met [4].COC has the advantages of being highly effective, simple, and reversible. Fertility control is achieved through a combination of suppression of ovulation, alteration of cervical mucus properties, alteration of endometrial morphology and function, and alteration of fallopian tube function. Most COC dosing regimens are started on days 1-5 of the menstrual cycle with one tablet per day; the drug is discontinued for 4-7 d, with a small amount of vaginal bleeding known as withdrawal bleeding during the discontinuation period. The WHO study on the effectiveness of COC contraception found that the main causes of COC contraceptive failure were irregularity and missed doses. The likelihood of pregnancy is greatest when 3 or more pills are missed in a cycle. In addition, the contraceptive effect of COC can be interfered with if drugs that affect the metabolism of liver enzymes are being used at the same time [5-6]. Women who tend to use COC believe that this method of contraception can be controlled by themselves and can be discontinued at any time without more help from family planning providers and without interfering with their sex life. Currently, in addition to its widespread clinical use as contraception and prevention of unwanted pregnancy, the health benefits associated with COC use are increasingly recognized by the general public, and its known health risks are rare and safe and appropriate for most healthy women of reproductive age [6].Contraindications to COC use are shown in Table 2 and cautionary use in Table 3.Drug interactions for COC: (1) Antiretroviral therapeutic drugs: ritonavir and other protease inhibitors; (2) anticonvulsants: phenytoin sodium, carbamazepine, barbiturates, paromidone, topiramate, oxcarbazepine, lamotrigine; (3) antimicrobial therapeutic drugs: rifampin, rifabutin.