If treatment is maintained with the lowest dose of inhaled hormones for 1 year and control is achieved, current national and international guidelines for asthma suggest that the drug can be discontinued for observation. However, there is little evidence from studies conducted on the effect of drug discontinuation on the disease. According to our clinical observation, asthma can be discontinued for different periods of time, which may be several months or longer, or even several years, and some patients may experience exacerbation of asthma or asthma attacks when they encounter various external triggering factors. Current guidelines also suggest that if an asthma exacerbation occurs after discontinuation of medication, treatment should be re-evaluated and restarted. Patients with asthma should adhere to long-term treatment because asthma is a chronic disease and the basis of the disease exists in the form of airway inflammation and airway hyperresponsiveness. In fact, many hospitals are not equipped to evaluate asthma patients for airway inflammation, and improvement in airway hyperresponsiveness. If medication is reduced or stopped based solely on the duration of treatment, a proportion of patients may regain control. Therefore, asthma patients should fully communicate with their physicians and carefully evaluate before taking appropriate measures when reducing and discontinuing medications.