Premature ejaculation is the most common sexual dysfunction in men, with approximately 20-40% of men experiencing premature ejaculation at some point in their lives. The definition of premature ejaculation has not yet been defined in a unified and precise language. Premature ejaculation can be considered when the following conditions are present: 1. ejaculation always occurs before, during or shortly after entering the vagina (usually less than 1 minute); 2. inability to control delayed ejaculation; 3. negative personal emotions, such as distress, worry, frustration, avoidance of sexual behavior, etc. How should premature ejaculation be treated? Premature ejaculation needs comprehensive treatment, including behavioral therapy (very important, it is about the effect after the end of treatment), topical local anesthetic drugs (for those with sensitive glans, not suitable for patients with poor erection), oral antidepressants, etc. Among them, oral antidepressants are the first-line treatment for premature ejaculation. How to view antidepressants correctly? The scientific name of antidepressants is collectively known as 5hydroxytryptamine reuptake inhibitors, and the main indications are depression, obsessive-compulsive disorder, and so on. It can cause gastrointestinal discomfort, nausea, anorexia, diarrhea, nervous disorder, headache, anxiety, nervousness, insomnia, drowsiness, sweating, trembling and dizziness or light-headedness, and even the risk of syncope. It is even more harmful if the drug is stopped privately. This is the main reason why many patients are reluctant or afraid to take them. The reason why antidepressants were first used to treat premature ejaculation was because doctors found that a significant percentage of patients taking antidepressant treatment had difficulty ejaculating or even did not ejaculate. This was actually a side effect of the drug, and it was later used to try to treat premature ejaculation, to the point where it has now become the drug of choice for premature ejaculation. The dosage and duration of medication used to treat premature ejaculation are different from those used to treat depression, so the incidence of clinical side effects is also much less than that of treating depression. The most common clinical side effects are mild dizziness and stomach discomfort, which mostly resolve on their own within a week and do not affect the patient’s life. For individual patients with significant dizziness, it is recommended not to engage in overhead work, driving and other behaviors. The newly marketed dapoxetine, trade name Bilirubicin, is currently the only 5hydroxytryptamine reuptake inhibitor approved by the State Food and Drug Administration for the treatment of premature ejaculation. The drug avoids the shortcomings of traditional antidepressants that need to be taken daily, and only needs to be taken 1 to 3 hours before intercourse, greatly reducing the adverse effects of the drug.