The HIV quadruple test, also known as the HIV antigen-antibody combination test, detects HIV P24 antigen and HIV antibodies. HIV antigens and antibodies can be detected in the patient’s body about 2-3 weeks after infection, and most patients can be ruled out after 3 weeks with a quadruple test. Special circumstances should also be ruled out, such as the use of immunosuppressive drugs, or patients who have undergone chemotherapy or are taking special medications that suppress immune function, thus affecting antibody production and affecting detection. HIV-RNA testing can be performed at this time and is relatively more accurate.