Prenatal diagnosis not only detects incurable or untreatable abnormalities in the fetus before birth in order to terminate the pregnancy, but also helps doctors understand the condition of the fetus with curable diseases so that they can treat the abnormal fetus or newborn with medication or surgery at the right time before or after birth. It also enables the family of the affected child to understand the status of the pregnancy and to have a good psychological expectation of the disease in the new member of the future family, and the prospect of treatment. Prenatal diagnostic methods: amniocentesis, chorionic villus extraction, fetoscopy, umbilical vascular puncture, etc. are invasive prenatal diagnostic methods depending on the situation. Ultrasound, MRI, and maternal serology are non-invasive prenatal diagnostics. These are implemented by the corresponding specialized technical departments. Second, the complexity of prenatal diagnosis Because prenatal diagnosis involves serious issues such as whether the fetus has a disease, what kind of disease, whether it can be treated, when to treat it, and whether to terminate the pregnancy, prenatal diagnosis is a comprehensive, complex and cautious process, which includes the whole pregnancy period. Moreover, due to the changes of the disease itself, doctor’s experience and technical limitations, some diagnoses need to be confirmed and dealt with in the postnatal follow-up observation. Prenatal diagnosis of diseases 1, prenatal diagnosis try to clarify the problem: whether the fetus is suffering from a certain disease or multiple diseases, if suffering from a certain disease need further examination and follow-up and confirm the diagnosis method; confirm whether the disease can be treated postpartum prognosis and whether to terminate the pregnancy; whether the need for immediate postpartum surgery. 2.Observation: Once you suspect that the fetus has abnormalities, in addition to the cycle of labor and delivery, you should consult with prenatal diagnosis clinics such as gynecology, pediatrics, pediatric surgery, ultrasound, etc., and regularly review and make corresponding examinations as required by the doctor. 3. Termination of pregnancy: For serious abnormalities, pregnancy can be terminated in time, but a multidisciplinary exact diagnosis is needed. Anencephaly, Down’s syndrome, polycystic kidney, etc. 4. prenatal treatment: because the mother and fetus take risks at the same time, it can cause complications such as bleeding, infection, preterm labor and miscarriage, so the pros and cons should be weighed and implemented with caution. Whether to implement when to implement should be decided and implemented in the specialist hospital specialist team. Postpartum treatment 1, early surgery: some diseases should be such as diaphragmatic hernia, small intestine atresia, anal atresia, abdominal wall cleft, umbilical bulge, esophageal atresia can be life-threatening, requiring immediate postpartum referral for early surgery. 2.Late surgery: giant colon, teratoma, choledochal cyst, mesenteric cyst, annular pancreas, hypertrophic pyloric obstruction, etc. 3.Surgery according to the situation after observation: solitary hydronephrosis, vesicoureteral reflux, vascular tumor, etc. (This article is authorized by Dr. Liu Erected.)