Anorectal malformations occur as a result of disorders that occur during normal embryonic development. The causes of anorectal developmental disorders are still unknown. In recent years, many scholars believe that anorectal malformation is related to genetic factors. There is a family history of morbidity accounted for 1-9%. Studies have shown that it is related to the HLA gene located in the short arm of chromosome 6, and HoxA-13 and HoxD-13 may be one of the causative genes. Some foreign research to the early and mid-pregnancy rats inhalation of chloroform, or injected through the gastric tube vinylthiourea, or to the intraperitoneal injection of retinoic acid, or to take adriamycin, etc., can make female rats produce anorectal malformations of the rat pups, the incidence rate of deformity is as high as 30% -90%, the type of deformity and pathological changes and the human anorectal malformations similar to the taking of these drugs can cause teratogenicity of the progeny.