Pyelonephritis treatment drugs include quinolone antibiotics (such as ofloxacin, etc.), semi-synthetic penicillins (amoxicillin), cephalosporins (cefuroxime) and so on, which need to be used under the guidance of a professional doctor. 1. Ofloxacin is a quinolone antibiotic, adverse reactions include gastrointestinal reactions (nausea, vomiting and diarrhea, etc.), central nervous system toxicity (insomnia, headache or mental abnormality, etc.), photosensitivity (itchy erythema at the site of exposure, etc.), cardiotoxicity (ventricular fibrillation, tip-twisting ventricular tachycardia, etc.) or cartilage damage. 2. Amoxicillin is a semi-synthetic penicillin, the most common adverse drug reactions are diarrhea, nausea and rash. Penicillin allergy and penicillin skin test positive patients are prohibited. For other – lactam agents (such as cephalosporins, carbapenems, monocyclic – lactams) have serious rapid hypersensitivity (such as allergic reactions) is prohibited. 3. Cefuroxime is a cephalosporin, and is contraindicated in those who are allergic to cephalosporin antibiotics. Patients with pyelonephritis should go to the hospital in time, under the guidance of a professional physician to choose the drug treatment, do not take medication on their own.