Stomach discomfort leading to chest tightness and shortness of breath may be caused by indigestion, angina, gastroesophageal reflux and other reasons. You can take gastrointestinal stimulants, acid suppressants, nitroglycerin and other treatments. 1. Indigestion: gastrointestinal peristalsis slows down leading to indigestion, food stagnation in the gastrointestinal tract, causing gastric discomfort, abdominal distension, food stagnation in the epigastric region will affect the respiratory movement of the lungs in the chest cavity, causing chest tightness and shortness of breath symptoms. You can take gastrointestinal stimulating drugs and digestive drugs, such as domperidone and digestive enzyme tablets, to reduce the symptoms of indigestion. 2. angina: some patients with angina attack symptoms are not typical, can appear epigastric pain, mistaken for stomach discomfort, angina leads to coronary artery spasm heart blood supply is affected, resulting in chest tightness and shortness of breath symptoms. Nitroglycerin can be taken orally to dilate blood vessels, improve coronary circulation, epigastric discomfort and chest tightness and shortness of breath symptoms will improve. 3. Gastroesophageal reflux: Gastroesophageal reflux is the reflux of gastric acid into the esophagus, which can irritate the esophagus and diaphragm, causing chest tightness and shortness of breath and epigastric discomfort. You can take omeprazole, mosapride and other drugs to inhibit gastric acid and promote gastrointestinal peristalsis to reduce the symptoms of epigastric discomfort and chest tightness and shortness of breath. There are many other causes of chest tightness and shortness of breath due to gastric discomfort. If the symptoms continue to be unrelieved, you should go to the hospital in time to improve the examination and give targeted treatment after clarifying the cause of the disease.