A mole on the face may seem like a common thing, and some moles are also known as “beauty moles” and “fortune moles”, which most people would consider harmless even though they may not add color and wealth. However, there are some seemingly common “moles” that require vigilance and attention to their changes, so as not to miss out on health because of these “time bombs” that may lurk under the skin for a long time. Recently, two patients in their 50s were seen in our department. An old teacher came to our clinic because she had a “black mole” on her nose for 2 years, which initially turned from a small papule-like rash to a slightly hard nodule, but gradually grew to the size of a soybean in the last few months. Another woman came to the doctor because a 1 cm-sized “black mole” next to her nose had been breaking out and bleeding when she wiped her face for the past six months. After the doctor’s consultation and treatment, she was scheduled for surgical excision, wound reconstruction and pathological examination, which revealed that she had basal cell carcinoma and squamous cell carcinoma, respectively. Many people think that it is normal to have a mole on the skin or a sudden growth of a mole, especially the longer “moles” feel safe, and even if they grow slowly, they do not pay much attention to them, but in fact, there is a certain difference between ordinary pigmented moles and some potential facial or neck skin tumors, so proper vigilance can lead to timely diagnosis and Adequate vigilance can lead to timely diagnosis and treatment. Common pigmented nevi (nevi in the usual sense) tend to have a smooth surface, flat or above the skin surface, and may have hair growth and slow growth. Basal cell carcinoma is the most common skin malignant tumor, which often appears as grayish white, light brown or waxy nodules or hyperpigmented plaques on the skin surface, and can slowly increase in size or be accompanied by ulcers. 70% to 90% of these tumors occur on the head and face (nose and perinasal area are the most common), and they easily cause cosmetic damage, and the onset of the disease is slow, so it is often not easy to detect early and delay the diagnosis and treatment. After several weeks or months of sun exposure, the center of the ulcer may break down and form an ulcer with a granular base, covered with plasma secretions, and the edges curled up like mother-of-pearl, hard and with dilated capillaries. In contrast, squamous cell carcinoma starts as warty keratinized patches or light red or yellowish nodules, with keratinized spikes at the central tip of the nodules, which can easily break down to form ulcers and bleed easily when touched, and can develop deeper to invade muscles and bones, with a hard base, papillary, cauliflower-like or subterranean appearance, which can be accompanied by necrotic tissues and discharge fishy fluid, with rapid development, great destructiveness, easy metastasis, and especially easy invasion of Patients occasionally have unbearable pain. However, it should be noted that even if some may be ordinary nevi (or some benign skin lesions) are irritated by sunlight, frequent friction, corrosive dabbing, laser, freezing, etc., they may easily increase in size and harden, change in shape and deepen in color, or appear broken, oozing, scabs, rough edges with cracks, and uneven surface, all of them have the possibility of malignant transformation. If biopsy is confirmed or highly suspected to be basal cell carcinoma or squamous cell carcinoma, surgical excision is the main treatment. However, since the disease often occurs in the nasal face, clinical cure and facial aesthetics must be considered. However, since the disease often occurs in the nose and face, clinical cure and facial aesthetics must be considered. Especially for basal cell carcinoma, the recurrence rate is extremely low after surgical resection. In terms of prevention, sun exposure should be avoided as much as possible, sunbathing or dark tanning should be moderate, and protective measures should be enhanced for living and working environments with chemical toxic substances (especially arsenic agents) or electromagnetic radiation, while existing skin nevi or skin damage should not be stimulated by frequent rubbing or other unnecessary points, scraping or burning. For “nevus” or other suspicious nodular lesions on the nose and face that have a tendency to increase in size, you can go to a regular hospital for early consultation and treatment.