Chromosomal abnormalities of embryo or fetus are the most common cause of early miscarriage, accounting for about 50%-60%, and then other causes are excluded. Therefore, only a small percentage of patients have miscarriage due to hormone deficiency and the application of exogenous hormones to promote the growth and development of embryo should be under the condition that the pregnant woman’s own hormone secretion is insufficient. If it is not a hormone deficiency, too much hormone supplementation will only cause adverse effects to the fetus and the pregnant woman. Excessive progesterone can lead to dilated renal pelvis and even hydronephrosis, abnormal genital development in many male fetuses, and genital tumors in female fetuses after puberty.