Eugenol, known generically as recombinant human interferon alpha-2b, and imiquimod are both used to treat warts. For warts that have already formed, imiquimod is more effective at removing warts than recombinant human interferon alpha-2b. Imiquimod cream is a non-nucleoside immunomodulator, which, through topical application, stimulates the body to produce various cytokines, such as interleukin and tumor necrosis factor, thus exerting the ability to remove the virus. The main causative agent of warts in the body is HPV, imiquimod cream stimulates the body to produce an immune response, which in turn removes the warts in order to achieve the therapeutic purpose. Recombinant human interferon alpha-2b exerts antiviral, cell proliferation inhibition and immune regulation effects by specifically binding to membrane receptors on the cell surface. The effect of interferon is mainly to inhibit viral replication, inhibit and reduce the recurrence of infection, and by topical application, it cannot make the already existing warts fall off. Therefore, imiquimod wart removal is better than recombinant human interferon alpha-2b. Both imiquimod and recombinant human interferon alpha-2b, need to be used under the guidance of a doctor, allergic to these two drugs is prohibited, if the use of the period of discomfort, it is recommended to promptly consult a doctor.