There are very many liver-protective and anti-yellowness drugs available in the clinic. Liver-protective drugs are most commonly used clinically to reduce transaminases, and can be mainly divided into glycyrrhetinic acid preparations, antioxidants and membrane cell stabilizers. The representative drugs are compound glycyrrhetinic acid, reduced glutathione and polyenyl phosphatidylcholine, which are also the most commonly used drugs in clinical practice and are also the ones with better effects. Among them, compound glycyrrhizin has the strongest effect in lowering transaminases, followed by strong anti-allergic and anti-inflammatory effects. The most commonly used drug to reduce yellowing is adenosylmethionine, which is available in both oral and intravenous formulations. In addition, many proprietary Chinese medicines can also play the role of liver protection and anti-yellowing, such as anti-inflammatory and bile tablets, Shu Bile tablets, Yin Gardenia Huang oral liquid, etc.. Clinically, different drugs can be used according to different conditions, both individually and in combination. Milder patients can consider the use of oral preparations, while serious patients also need to timely application of intravenous infusion. However, the liver medicine is not effective in all cases of elevated aminotransferases and bilirubin, and treatment of the cause is the most important.