The main causes of chest tightness from drinking are alcohol stimulation and a history of heart disease. 1. Alcohol stimulation: After alcohol enters the body, it first stimulates the gastrointestinal tract, which may cause chest discomfort. Then it will be broken down by the liver’s ethanol dehydrogenase into acetaldehyde, which can stimulate the heart and gastrointestinal mucosal vasodilatation, so that the heart’s oxygen consumption increases, resulting in transient chest tightness, shortness of breath, palpitations and other symptoms. 2. History of heart disease: If there is a history of heart disease, such as coronary artery stenosis, coronary artery atherosclerosis, etc., after a large number of large amounts of continuous drinking, alcohol will stimulate blood vessels to dilate and then constrict, aggravating the degree of poor circulation of blood in the heart, which will lead to chest tightness, panic, and other clinical symptoms, and even angina pectoris. If you drink chest tightness, you should go to the regular hospital in time to find out the cause of the disease, and under the guidance of a professional doctor to choose a suitable method of treatment.