The difference between high and low blood pressure is pulse pressure, which is 20-40 mmHg in healthy young people.Increased pulse pressure can be categorized into physiological and pathological. Physiological pulse pressure increase is mostly seen in the elderly, due to arterial wall sclerosis, blood vessel elasticity decreases, the systolic pressure (high pressure) increases while the diastolic pressure (low pressure) decreases, resulting in increased pulse pressure, which is a normal physiological scene, usually without special treatment. Pathological increase in pulse pressure can be seen in a variety of diseases that cause increased cardiac output, such as hyperthyroidism, severe anemia, aortic valve insufficiency. Hyperthyroidism is diagnosed in conjunction with thyroid hormone test results and can be treated with medication (propylthiouracil, etc.) or surgical removal of the thyroid gland; Severe anemia can lead to an increase in heart rate, which can lead to an increase in pulse pressure. The pulse pressure can be normalized after correcting the anemia (iron supplementation, treatment of the cause of the anemia, etc.). Aortic valve insufficiency can also cause an increase in pulse pressure, which can be diagnosed by cardiac ultrasound to determine the severity of the disease. Mild aortic valve insufficiency that is asymptomatic does not require treatment, and can be reviewed regularly. Surgery, such as aortic valve replacement, is usually recommended for patients with moderate to severe aortic insufficiency. There is no need to be alarmed when the pulse pressure increases, and it is recommended to consult a doctor to determine whether treatment is needed and how to treat it, taking into account the clinical symptoms.