It is not suitable to apply vitamin E to the skin after mole spotting, and vitamin E is not meaningful for wound healing. Instead, topical antibiotic creams such as erythromycin ointment, fusidic acid cream or mupirocin cream should be used to prevent skin infection. For larger and deeper nevus, topical application of recombinant bovine basic fibroblast growth factor can be used to promote skin repair and wound healing to reduce the chance of leaving pits. In addition, after mole spotting, you should pay attention not to touch water to avoid infection, and some people may have hypopigmentation or loss of pigmentation or hyperpigmentation after mole spotting. There is no way to prevent hypopigmentation or depigmentation, but hyperpigmentation is mainly related to personal constitution and ultraviolet radiation, so you should pay attention to sun protection and physical shading after mole spotting.