Many mothers-to-be have mixed emotions when it comes to conceiving a baby, from being “upgraded” to becoming a mother to how to ensure a healthy birth. In recent years, both what we see and hear, and what happens around us that we can personally feel, is that the ranks of the “birth control army” are growing. In the major parenting forums, we find that there are many people who have suffered from embryonic abortion and pre-eclampsia during pregnancy. Many mothers-to-be are talking about their troubles online and passing on their experiences to each other in a warm manner to help their babies get through the difficult times. According to the latest data, the number of people who need birth control is increasing year by year, according to the survey: the number of people who need birth control in Nanjing has increased 60% in 4 years; and the number of people who need birth control in Qingdao has increased 6 times in 10 years. Why are people so “vulnerable” nowadays? Why are people more delicate than in our parents’ time when the material conditions are better? 1.What are the reasons for the growing army of birth control? The causes of pre-eclampsia are diverse and complex, mainly divided into two aspects: the pregnant woman herself and the fetus, among which the maternal factors include the following: endocrine dysfunction such as luteal insufficiency, thyroid insufficiency, etc., infectious diseases, high fever, severe anemia, severe malnutrition, radioactivity, exposure to toxic substances and reproductive tract abnormalities such as unicornuate uterus, double uterus, longitudinal uterus, uterine fibroids and The fetal factors are most likely to cause preterm abortion. The most prominent fetal factor is the abnormal number and structure of chromosomes in the fertilized egg, which accounts for about 25% of all miscarriages. According to statistics, 100% of miscarriages before the fourth week of pregnancy are malformations, 75% of which are chromosomal abnormalities, and about 12% of miscarriages before the 12th week of pregnancy are malformations, 5.3% of which are chromosomal abnormalities. In addition, TORCH infections can cause maternal and infant infections.TORCH refers to pathogens that can cause congenital intrauterine infections and perinatal infections resulting in perinatal malformations.It is an acronym for a group of pathogenic microorganisms, of which T(Toxopasma) is Toxoplasma gondii, R(Rubella.Virus) is rubella virus, C(Cytomegalo.Virus Virus) is cytomegalo, and H(Herpes.Virus) is herpes simplex type I/II. Pregnant women are prone to primary infections due to endocrine changes and decreased immunity, and potential viruses in previously infected pregnant women are also prone to recurrent infections due to activation. When viraemia occurs in pregnant women, the virus can spread through the placenta or birth canal and infect the fetus, causing premature birth, miscarriage, stillbirth or malformation, as well as causing damage to multiple systems and organs of the newborn, resulting in various degrees of mental retardation and other symptoms. Especially in the first trimester of pregnancy, when the embryo is in the organ-forming stage, infection by the virus can destroy cells or inhibit cell division and proliferation. TORCH infection affects the quality of the population and has an important relationship with eugenics. Immunological factors are also the “culprits” of pre-eclampsia, especially habitual spontaneous abortion. The last point that cannot be ignored is that environmental factors are one of the external causes of pre-eclampsia. The fact that environmental factors affect reproductive function has been recognized by the medical profession as causing not only menstrual disorders in women, abnormal function of the endocrine system, but also serious genetic damage to germ cells, causing miscarriage, stillbirth, premature birth, fetal malformation or fetal and neonatal malignancies in women after conception. 2. Who is the main force of this birth control army? Among the people who come to the birth control, there are staff of organs, editorial staff of TV stations and newspapers, teachers of schools, staff of foreign enterprises, even doctors and nurses of hospitals, all walks of life, the majority of them are white-collar workers, and. These people usually physical examination of the indicators are very normal, but once the pregnancy, it is not able to smoothly through the pregnancy, it can be seen that in addition to organic lesions, environmental pollution, diet and other factors work fast-paced, mental stress is an important reason, excessive mental stimulation can cause endocrine disorders and cause miscarriage. The number of pregnancies at an advanced age is also an important factor in the increase of birth control. The best age for women to have a baby is 25-29 years old. However, nowadays, urban women are more likely to be over 30 years old and not yet married, and the age of childbirth is delayed until after 35 years old. According to statistics, the spontaneous abortion rate of pregnant women between the ages of 25 and 35 is about 15%, and the spontaneous abortion rate is as high as 40% at the age of 40. The older women are difficult to get pregnant, easy to miscarry, and become the main force of the birth control army. 3.How to determine pre-eclampsia miscarriage? (1) Medical history: History of menopause and early pregnancy reaction. (2)Symptoms: small amount of vaginal bleeding, accompanied by pain in the abdomen or backache. (3)Pregnancy test: Positive urine pregnancy test. (4)Gynecological examination: the opening of the cervix is not open, the uterine body is soft and the size is consistent with the gestational week. (5) Ultrasound examination: B-type ultrasound examination of uterine size, gestational sac or embryo (fetus) development is consistent with the gestational week. (6) Basal body temperature measurement: maintain the level of luteal phase (maintain high temperature curve). (7) Serum chorionic gonadotropin (β-HCG) and progesterone (P) levels are basically consistent with gestational week and ultrasound results (gestational sac size, embryo development). 4.How are serum chorionic gonadotropin (β-HCG) and progesterone (P) values determined and under what circumstances is progesterone supplementation necessary? What is the appropriate supplementation? When women with early pregnancy come to the hospital, doctors usually recommend that patients have their blood drawn for beta-HCG and progesterone (P) to determine whether they have a pre-eclampsia by their changes. After a woman becomes pregnant, the placenta secretes the hormone HCG, and one of the functions of HCG is to stimulate the corpus luteum to secrete progesterone (i.e. progesterone, also called progesterone). Progesterone is necessary for the maintenance of pregnancy as it has the function of suppressing uterine activity to allow safe fetal growth. Therefore, a low progesterone level indicates that fetal development or luteal function may not be normal. In normal intrauterine pregnancy, β-HCG is detectable in the blood 7-10 days after fertilization of the egg, i.e., around day 23 of the menstrual cycle, and its concentration increases with the week of gestation. During the first 3 weeks after fertilization, the HCG doubling time is approximately 1.2-1.4 days; during 4-6 weeks it is 3.3-3.5 days. During the 8th week of pregnancy, HCG increases exponentially, reaching a peak of 200,000 IU/L in the 10th week, slowly decreasing to 1/5 of the peak over the next 10 weeks and remaining there until delivery. There are many factors affecting the amount of HCG in the blood, such as the time of menopause, the site of embryo sac implantation, the number of trophoblast cells, and the quality of trophoblast cells, etc. The variation of HCG between individuals is very large and varies up to 20-fold. Therefore, it is difficult to judge the prognosis of preeclampsia with a single beta-HCG result, and dynamic observation and close follow-up are needed. Progesterone is mainly secreted by the ovaries and is a steroid hormone containing 21 carbon atoms. Progesterone is mainly progesterone, 20-hydroxyprogesterone and 17-hydroxyprogesterone, with progesterone having the strongest biological activity. Since the content of progesterone receptors in target organs is regulated by estrogen, progesterone must act on the basis of estrogen. The gestational corpus luteum must secrete sufficient progesterone during 8-10 weeks of gestation to normalize the pregnancy. Progesterone is produced by the gestational corpus luteum in early pregnancy and by the syncytial trophoblast after 8-10 weeks of gestation to maintain the pregnancy. Progesterone relaxes the smooth muscle fibers of the uterus and reduces excitability, as well as decreasing the sensitivity of the pregnant uterus to contractile hormones, thereby reducing uterine contractions and inhibiting the amplitude of rhythmic contractions of the fallopian tube muscle. There are currently two units of progesterone values used in major hospitals, the old unit ng/ml, multiplied by 3.12, is the new unit nmol/L. In the old unit, a progesterone (P) value <5ng/ml suggests an abnormal embryo, <10ng/ml requires fetal preservation, >20ng/ml can rule out ectopic pregnancy, and before 7 weeks of pregnancy: 18-32ng/ml (average value is 24ng/ml). In general, pregnancy can be maintained by maintaining progesterone values above 20ng/ml. From this, the progesterone (P) value in new units of nmol/L can be deduced. And women with early pregnancy whose progesterone value is lower than this threshold are prone to signs of preterm abortion. Appropriate supplementation of progesterone can maintain a certain level of progesterone and vaginal bleeding will stop. 5.How to keep the pregnancy in preterm miscarriage? The most important thing for pregnant women is to rest, relax and have regular checkups, and not to be overly anxious. During pregnancy, pay attention to proper nutrition, avoid spicy and hot products and pay attention to dietary hygiene to prevent intestinal infection. During the third month of pregnancy, do not lift heavy objects, do not climb high, do not travel far, avoid fatigue, so as not to hurt the fetus; pay attention to the first three months of pregnancy to avoid sexual intercourse. It is important to point out that pre-eclampsia miscarriage ≠ miscarriage. If the embryo is normal, after rest and treatment, the cause of miscarriage will be eliminated and the bleeding will stop, and the pregnancy can continue. However, if it is caused by an abnormal embryo, the pregnancy cannot be kept, even if you try hard. Pregnant women who find themselves with signs of pre-eclampsia should go to the hospital as soon as possible for examination to clarify the cause and the condition of the fetus and to exclude genetic problems. However, it is important to note that unnecessary vaginal examinations should be minimized to reduce the irritation to the uterus. And when vaginal bleeding is high, gynecological examination should be performed to rule out the possibility of inevitable miscarriage or inflammation of the cervix. There is no need to force birth control in case of preterm miscarriage. From the perspective of eugenics, pre-eclampsia miscarriage is also a kind of natural “survival of the fittest”. The next baby may be a healthy one.