Chest tightness and breath-holding at night need to exclude pathological factors, which are organic lesions: 1. Respiratory system disorders. The most common is an acute attack of bronchial asthma, which is characterized by obvious symptoms in the evening and early morning, mainly manifested as chest tightness, breath-holding, coughing, wheezing, and even dyspnea, and in severe cases, telangiectatic breathing. Most of this disease has allergic triggers, so it is recommended to check lung function, allergen test, and perform excitation test or diastolic test if necessary to clarify the diagnosis. Other diseases of the lungs also need to be excluded, such as airway obstruction, tracheal tumors, goiter, emphysema, chronic bronchitis, pulmonary atelectasis, pulmonary infarction, pneumothorax, etc. It is recommended to visit a regular hospital and perform systematic examinations to clarify the condition. 2. Heart disorders, including coronary heart disease, acute cardiac insufficiency, chronic cardiac insufficiency, cardiomyopathy, etc., may also have symptoms of nocturnal chest tightness and breath-holding. 3. Reflux Esophagitis, due to the change of body position and possible previous chronic gastric disease, cardia orifice relaxation disease, etc.. This causes a small amount of gastric contents to reflux into the pharynx and stimulate the airway, so that the airway smooth muscle spasm leads to breathlessness, chest tightness, most of these patients occur at night after lying down. 4, environmental, climatic and mental and emotional changes, can lead to some patients with symptoms of chest tightness, breathlessness, such as long-term in a confined space, low air pressure, after severe emotional fluctuations. Most of these patients do not have organic lesions, and can be relieved by paying attention to the improvement of the environment and the smooth flow of emotions.