Cephalosporin is useful when wisdom tooth pericoronitis is caused by staphylococci and streptococci, and should be combined with anti-anaerobic treatment when anaerobes are present. If symptoms are severe, surgical treatment with incision and drainage is required. Wisdom tooth pericoronitis is usually caused by localized food impaction and bacterial colonization, which can be treated with antibiotics. Cephalosporin is effective for staphylococcal and streptococcal infections. Anaerobic infections are usually present in the case of pericoronitis, so antibiotics that target anaerobic bacteria, such as metronidazole, are more effective. In addition, antibiotics such as cephalosporin may have limited effect if symptoms are severe or recurrent in the case of wisdom tooth pericoronitis. If there is a localized abscess with systemic symptoms, incision and drainage is needed; if there is an impacted wisdom tooth, wisdom tooth extraction is needed. If you have wisdom teeth pericoronitis, go to the hospital in time, the use of the above drugs need to follow the doctor’s advice.