Lupus erythematosus usually refers to systemic lupus erythematosus (SLE), which usually does not go away. SLE cannot be cured yet. Usually, after systematic treatment, skin lesions such as erythema pteronyssinus can fade away in about 5 to 7 days in some patients, but some patients may have prolonged skin lesion fading due to serious illness or low sensitivity to drugs. Most of the patients can be controlled after active systematic and standardized treatment, which can effectively slow down the progression of the disease. Systemic lupus erythematosus is an autoimmune disease with pathogenic autoantibodies and immune complexes forming and mediating damage to organs and tissues. Clinically, there is often multi-system involvement, and a variety of autoantibodies represented by antinuclear antibodies are present in the serum. The common causes of autoimmune disease include genetic factors, environmental factors and estrogen. Its main clinical manifestations include fever, malaise, pteronyssinus erythematosus, plasma membrane inflammation, joint pain, proteinuria, and so on. As SLE is difficult to treat, patients should build up confidence and accept treatment actively. At the same time, patients should avoid sunlight and take measures to protect themselves from the sun; avoid getting cold and flu, and exercise properly to enhance immunity. Through active and standardized treatment and daily care, SLE can achieve ideal treatment effect. SLE cannot be cured yet, and generally speaking, it will not disappear. Therefore, it is recommended that patients should go to the hospital in time, follow the doctor’s instructions for standardized treatment, and actively control the condition in order to slow down the development of the disease.