Mycoplasma infections of the urinary and genital tracts are called mycoplasma urinary tract infections. Mycoplasma is a group of the smallest microorganisms between bacteria and viruses that are known to live independently. There are seven different species of mycoplasma detected from the genitourinary tract, mainly Mycoplasma humanum (MH) and Mycoplasma urealyticum (UU). Extensive literature has shown that they are among the most common pathogens of genitourinary tract infections. In recent years, the pathogenic incidence of Mycoplasma genitalium (MG) has been on the rise year by year and is of increasing concern. 1, symptoms and signs Mycoplasma-induced urinary sensation, its clinical manifestations are similar to the general bacterial urinary sensation. There can be fever, lumbago, bladder irritation and urinary sediment leukocytosis and other acute pyelonephritis manifestations; can also be manifested as lower urinary tract infection symptoms; typical performance is urethral tingling and mild urinary pain and burning sensation, mild redness and swelling of the urethral orifice, often with plasma or plasma-purulent urethral discharge, thinner and less than gonorrheal urethritis discharge, or only in the morning found in the urethra with white film formation. Some patients may not have any signs and symptoms of urinary sensation at all and only have positive culture for genital tract mycoplasma. Therefore, the diagnosis is often missed clinically. Some data suggest that human mycoplasma is closely related to female infertility, ovarian abscess, tubal inflammation, hemorrhagic cystitis, etc. It can also cause prostatitis, epididymitis and infertility (oligospermia, weak spermia, deformed sperm), urinary stones, pyelonephritis, etc. in men. MH and UU are highly sensitive to tetracycline, MH is occasionally tetracycline resistant but sensitive to lincomycin. Commonly used clinical drugs are: tetracyclines (e.g. doxycycline hydrochloride, minocycline, azithromycin, etc.). It should also be noted that the spouse should be treated at the same time, as it can be cross-infected through the sexual life between husband and wife. 3, review Generally treated with sensitive antibiotics for about 10-15 days, can be stopped after 5-7 repeat examination, cure criteria is the disappearance of symptoms, no urethral discharge and urethral swab or prostate fluid or semen mycoplasma culture or PCR examination, no mycoplasma found, that is, cured. It is best for spouses to be examined at the same time to avoid recurrence. 4, preventive care Mycoplasma resistance to physical and chemical factors is weak, outside the human body only survive for a short time, human-to-human sexual transmission is its main mode of survival. Prevention of mycoplasma infection is mainly to avoid unclean sex and active treatment of carriers, the spouse or sexual partner of the patient should be treated together to prevent continued transmission.