The appearance of spider nevi on the skin of patients is usually closely related to liver function damage, and patients are advised to first check whether there are significant problems with liver function. When the liver is affected by pathological factors for a long period of time, it will lead to liver function damage, which will reduce the liver’s ability to break down and metabolize, making the inactivation of estrogen in the body ineffective, which may then stimulate microcirculation in the patient’s body, thus producing spider nevi. If liver function tests reveal a serious imbalance in transaminases, bilirubin and albumin, further search for the cause of liver function damage is required. Usually, liver function impairment is due to viral, alcoholic or drug-related hepatitis, or cirrhosis, all of which can lead to a long-term imbalance in liver function. Therefore, it is recommended that patients should apply drugs such as glutathione and magnesium isoglycyrrhizate while protecting the liver, as well as antiviral treatment, abstaining from alcohol and stopping the use of drugs that damage the liver, so that liver function can return to normal levels, then spider nevus can be effectively resolved and improved.