Chest tightness while sleeping is most commonly associated with heart problems. The first aspect of the early manifestation of chronic heart failure is that when sleeping, the body is in the recumbent position, so the amount of blood returning to the heart will increase and the sympathetic nerves will be excited, followed by chest tightness, shortness of breath, suffocating awakening and other symptoms, called nocturnal paroxysmal dyspnea. After sitting up or standing up and walking a few steps, the symptoms will disappear, these are the early manifestations of heart failure, which can be treated with small doses of diuretics or vasodilators. Secondly, coronary artery disease, commonly known as recumbent angina, can appear in sleep, that is, when lying down, chest tightness, shortness of breath, chest pain and other symptoms, the onset of the electrocardiogram, or the line of dynamic electrocardiogram monitoring, can be seen in the stage of myocardial ischemia performance. Calcium antagonists, such as nimodipine, or nitroglycerin or rapid-acting heart pills can be used to relieve the symptoms. However, if the number of episodes of chest tightness increases during sleep, or even accompanied by other symptoms such as chest pain and dyspnea, it is necessary to seek medical treatment in the hospital.