HPV vaccine is an inactivated virus vaccine, which does not affect the normal physiological cycle of women after injection, if women have irregular menstruation after HPV vaccine, it is generally considered that it is not related to the vaccine, but may be caused by mental factors, drug factors, gynecological diseases, etc. 1, mental factors: mental stress can cause endocrine disorders in women, resulting in menstrual disorders, by improving the poor lifestyle, adjusting emotions, avoiding stress, and appropriate exercise can alleviate the situation. The problem of menstrual disorders can be alleviated by improving poor lifestyle, adjusting emotions, avoiding excessive stress, and exercising appropriately. 4. Pregnancy: If menstrual disorders are manifested as no menstruation and there is a possibility of pregnancy, you can go to the hospital for relevant examination. It should be noted that a delayed or early menstrual period of no more than 7 days is also considered a normal cycle, in addition to the female menstrual cycle is not constant, if long-term menstrual irregularities need to go to the hospital to find the cause, the cause of treatment.