The main cause of nocturnal epigastric pain is peptic ulcer, which occurs when there is a gastric ulcer or a duodenal bulb ulcer. The pain of duodenal bulb ulcers gets better after eating, while the symptoms of gastric ulcers worsen after eating. Some patients with nocturnal epigastric pain should consider the relationship between tumors in the stomach. When tumor lesions appear, there is often nocturnal epigastric pain, most often accompanied by wasting, black stool, fecal occult blood, etc. Usually, when nocturnal epigastric pain appears, gastroscopy is needed to clarify the diagnosis. In addition, an ultrasound examination is needed to rule out biliary tract pathology.