In the clinical treatment of premature ejaculation disease, premature ejaculation due to masturbation is a very common phenomenon. In order to avoid the impact of this pathogenic factor on the organism, the following aspects should be done. First, cultivate good interests and hobbies, encourage more social activities, and reduce sensitivity to the opposite sex. Second, masturbation should be treated correctly, prevention is the main focus, the application of psychiatric treatment, psychological diversion methods, strengthen the construction of spiritual civilization and sex education, attention to the moral, intellectual and physical development of the three aspects of the overall development, to overcome the idea of too much concentration. Third, pay attention to the regularity of life and life mediation, avoid wearing too tight underwear, sleep on time, dinner should not be too full, sleep bedding should not be too warm, too heavy, sleep should not be supine and prone. Fourth, for adolescents who commit the habit of masturbation, they should build confidence and determination to quit masturbation, do not use exaggerated, intimidating methods, otherwise it will increase the burden of thought. Fifth, to overcome the habit of masturbation, determined to free themselves from the mental pressure of masturbation. Sixth, reduce the bad sexual stimulation, do not look at pornographic books, film and television, develop good hygiene habits, keep the vulva clean, wash often, remove dirt and other bad stimulation. The above is for reference only, the specific medication, treatment please according to the doctor’s face-to-face guidance shall prevail.