The difference between Bowen-like papules and acne vulgaris lies in the etiology, clinical manifestations, and pathologic examination. 1. Etiology: both are caused by human papillomavirus (HPV), Bowen’s papule is related to high-risk HPV (mainly HPV-16) infection, while acral eczema is mainly caused by low-risk HPV (mainly HPV-6 and HPV-11). 2. Clinical manifestations: Bowen-like papules are flesh-colored or reddish-brown, round, oval or irregular, appearing as flattened pigmentation, etc.; while acrodermatitis eczema has a papillomatous, cauliflower-like or cockscomb-like appearance, with lesions that are bright red in color. 3. Pathological examination: Bowen-like papules will cause slight anomalies of cells, similar to the manifestation of pre-cancerous lesions; while acrodermatitis eczema can be seen in the formation of cellular vacuoles, characterized by concave hollow cells. If you have any of the above manifestations or are diagnosed with Bowen-like papules or acute eczema, it is recommended that you go to the hospital in time for a complete examination and standardized treatment under the guidance of the doctor.