To prevent secondary infections, antibiotic ointments such as erythromycin ointment or Bactrim ointment should be applied twice daily. Depending on the condition, epidermal growth factor gel can also be given to promote the healing of the lesion. As nevi are usually benign pigmented diseases, care should be taken to avoid frequent rubbing or scratching, as frequent stimulation of nevi may increase the possibility of lesions. If a nevus becomes significantly larger, has uneven pigmentation, irregular edges, or other discomfort such as itching in a short period of time, it is important to go to the hospital promptly. Usually a dermoscopic examination is done to determine whether the nevus is likely to have lesions. Usually try not to scratch or pick the mole to avoid infection or other negative consequences due to irritation. Therefore, the main thing to prevent secondary infection is to pick the mole and apply antibiotic ointment topically.