There are many types of hypoglycemic drugs, and there is no such thing as the best one. Oral hypoglycemic drugs should be able to achieve better glucose-lowering effect if they are combined with diet control and exercise. If glucose-lowering is not satisfactory, they can be combined with subcutaneous injection of insulin, human glucagon-like peptide-1 (GLP-1) agonists and so on. Dietary control and proper exercise are necessary to achieve good therapeutic effect. 1. Oral hypoglycemic drugs: metformin, such as metformin tablets, metformin extended-release tablets; glimepiride, glipizide and other sulfonylureas such as lactulose promoters; reglaneride such as non-sulfonylurea hypoglycemic drugs; reducing postprandial blood glucose akarbose, belonging to the alpha-glucosidase inhibitor; insulin sensitizer pioglitazone and so on. 2. Insulin: subcutaneous injection of hypoglycemic drugs, hypoglycemic effect is very clear, oral drugs are recommended to apply when control is not good. 3. GLP-1 receptor agonist: Liraglutide, simethicone, better control of blood glucose, if oral hypoglycemic drugs and subcutaneous injection of insulin is not effective, it is recommended to apply, lowering glucose at the same time there is the effect of weight loss. For diabetic patients with medication, specific can consult the endocrinologist, under the guidance of the doctor to use drugs.