The causes of luteal insufficiency are closely related to the function of the thalamus, pituitary gland and ovarian gonads, mainly due to endocrine disorders, resulting in uncoordinated secretion of hormones, such as progesterone, luteinizing hormone and follicle stimulating hormone, and may be closely related to the lowering of the body’s immunity and the heavy mental stress. Luteinizing insufficiency is inevitably related to ovarian and endocrine function, mainly referring to the insufficient secretion of progesterone, which causes irregular vaginal bleeding and is not conducive to normal fertilization of the egg, and may lead to infertility and habitual abortion. If there are frequent abnormalities in menstrual cycle, period and volume, it is necessary to further investigate endocrine problems, excluding other causes such as gynecological inflammation, adnexal cysts, endometrial lesions and mental and emotional stress. Usually, the diagnosis can be made in conjunction with the menstrual cycle by checking the sex hormone panel. If low progesterone occurs during the luteal phase, it is considered luteal insufficiency and can be treated by progesterone supplementation. In conclusion, progesterone supplementation is needed in cases of menstrual disorders or habitual miscarriage, especially in the preparatory period or early pregnancy when tests suggest low progesterone. Patients with luteinizing insufficiency can eat more soy products in their diet, and they can generally recover after active treatment.