How long it takes to open the uterus after using Probeson to induce labor depends on the patient’s sensitivity to the drug, the number of births and other factors, and cannot be generalized. It is used to induce and promote cervical maturation and consists mainly of controlled-release dinoprost. The induction of labor varies from person to person because of the different sensitivity of the drug to probenecid. Generally, the mother should rest in bed for 2 hours after the drug is placed in the posterior vaginal fornix to allow for adequate absorption of the drug. In some women, contractions can occur 3-5 hours after the drug is administered, and in some patients, contractions can occur only after 24 hours. Generally, it takes about 12-24 hours to open the uterus after regular contractions in first-time mothers, and a little less time in menstruating mothers, and there are individual differences. It should be noted, however, that if the mother has premature rupture of membranes, Pulbenecid should not be used.