Mucoepidermoid carcinoma of the root of the tongue is serious and is a malignant tumor. Mucinous epidermoid carcinoma of the root of the tongue is the most common type of malignant tumor of salivary glands and needs to be taken highly seriously. Symptoms of mucoepidermoid carcinoma of the root of the tongue include pain, ear spillage, sensory abnormalities, facial nerve palsy, dysphagia, hemorrhage, and tooth clenching. Highly differentiated mucoepidermoid carcinoma grows more slowly, while low-differentiated mucoepidermoid carcinoma grows more quickly. The management of the primary focus of mucoepidermoid carcinoma of the tongue root is mainly regional radical resection, while if the tumor has invaded the surrounding tissues, the invaded surrounding tissues should also be resected. After the resection surgery, rehabilitation and postoperative adjuvant therapy should be actively carried out. If patients are diagnosed with mucoepidermoid carcinoma of the tongue root, they should keep a good attitude and actively accept treatment.