On October 29, 2015, the Fifth Plenary Session of the 18th Central Committee decided to fully implement the policy that a couple can have two children. Once the news came out, WeChat “circle of friends” and microblogging discussion or forwarding hot, that night many mothers and fathers, jumped to have a second child. The policy is coming, 80, 90, facing the birth or not? 60, 70 sisters, facing the arrival of the policy, the age of 35 years old, the risk of advanced maternity regardless, in the end can be born? A study shows that the rate of women older than 30 years old who have the desire to have a baby within one year is 75%; by the age of 35, the above figure drops to 66%; at the age of 40, the proportion is only 44%; and by the age of 45, pregnancy has become very difficult. With the rapid development of the economy, the young age of diseases and the change of people’s concept of childbirth, it is not as “casual” as before, everyone wants to have a beautiful, smart and healthy baby, which is the problem of eugenics. The following is the knowledge of how to prepare for pregnancy before the second child and how to make yourself “pregnant”. Ovarian reserve function, naturally, as age increases, the number of oocytes in the ovaries decreases through a spontaneous and progressive reduction and depletion by the process of atresia. The normal female reproductive life is 20 years, of which 25-35 years is the optimal reproductive age. As women age, their fertility gradually decreases, mainly due to a decrease in physiological ovarian reserve function. The decline is especially evident after the age of 35. Since the number of eggs in a woman’s ovaries cannot be accurately measured, age combined with ovarian reserve is currently a better way to comprehensively evaluate ovarian function. Therefore, women who are expecting a second child should be fully aware of the fact that their fertility decreases gradually with age and have their fertility evaluated and treated as early as possible. We recommend fasting tests on the 2nd to 5th day of menstruation: sex hormones, sinus follicles, and anti-Mullerian hormone antibodies to assess ovarian reserve function and decide on fertility options based on ovarian reserve. As we age, the incidence of various chronic diseases increases. If you have other medical conditions, you should seek professional medical advice on whether pregnancy is possible before conception. Some diseases such as uterine fibroids, adenomyosis, endometriosis, scarred uterus, thyroid disease, diabetes, heart disease, etc. need to be adjusted accordingly before pregnancy. If pregnancy is rushed before the disease is controlled, the chances of various pregnancy complications and fetal malformations will increase. Therefore, if you have some co-morbidities before pregnancy, you need to be consulted and treated accordingly. Eugenics screening to prevent birth defects. Pre-conception eugenics examinations are necessary because as we age, the likelihood of egg abnormalities increases, thus increasing the incidence of congenital malformations and dementia. The following tests are generally required: thyroid function, eugenics five or ten tests, folic acid metabolism disorders and other tests, as well as screening for infectious diseases such as hepatitis B, syphilis and AIDS to avoid vertical transmission from mother to fetus. If both couples are carriers, third-generation in vitro fertilization (PGD) technology is available to select healthy offspring. Infertility factor screening to ensure early pregnancy. After deciding to have children, for those who have placed the IUD for contraception, remove the IUD as soon as possible 3-7 days after menstruation, without sexual intercourse and without gynecological inflammation, so that the endometrium can recover as soon as possible to facilitate the fertilization of the egg. If you are taking oral contraceptives, you can stop taking them as soon as possible and start trying to conceive in the next month after you stop taking them. If necessary, tubal examination can also be performed to rule out infertility caused by adhesions or incompetence of the fallopian tubes. Our department carries out transvaginal 4-dimensional hysterosalpingography, which has the advantage of being radiation-free and does not require contraception for 3 months, so you can try to conceive normally the next month. Precautions for second pregnancy: 1. take oral folic acid 3 months in advance; 2. exercise to enhance physical fitness and control weight if you are overweight; 3. treat inflammatory diseases of reproductive organs, such as vaginitis, endometritis and adnexitis; 4. try to conceive after adjustment if you have endocrine abnormalities, such as polycystic ovary syndrome, hypothyroidism and hyperthyroidism; 5. consult a gynecologist if you have uterine fibroids or ovarian cysts to see if you can try to conceive; 6. 6. adjust emotions and arrange work and life reasonably.