Clinically, there are many patients who are only viral carriers and have a “minor triple-positive” status in the hospital, but there is a special situation, that is, although they are “minor triple-positive”, they have a positive HBVDNA. HBVDNA is positive, usually the viral load is not very high, 3-5 times fluctuating, viral replication exists, with or without liver function abnormalities; this state we call: E antigen negative chronic hepatitis B, this is a special disease state, and, liver function tests found that the transaminase level is elevated or fluctuating, but also can be normal. This is significantly different from what we usually call the quiescent HBV carrier state, which usually requires laboratory tests in the hospital to detect such a condition, which occurs due to a small regional variation of the virus in the body, the result of which can cause the virus to replicate without HBeAg being secreted into the serum, and thus the routine two-to-one half test simply indicates a ” However, studies have shown that this state usually allows the virus itself to evade the body’s immune control, exacerbating possible liver disease, and can quickly progress to early cirrhosis, with a high risk of subsequent cirrhosis loss and HCC. It is therefore required that we carefully assess the patient’s disease state, monitor serum transaminases and HBVDNA levels every 3 months, and adopt more aggressive treatment and intervention strategies; such patients are usually in need of treatment, and the duration of treatment may be longer.