Antibodies that can resist HBV infection are hepatitis B surface antibodies. Positive hepatitis B surface antibodies indicate immunity to HBV, mainly seen in recovery from acute hepatitis B or after hepatitis B vaccination. For a normal population, a routine check of the five indicators of hepatitis B is required. If the hepatitis B surface antibody is positive, hepatitis B vaccination is not required. If hepatitis B surface antibody is negative, hepatitis B vaccination is required. The hepatitis B vaccine requires three doses, and after the three doses are administered, a review is needed to see if antibodies have been produced. If the five indicators of hepatitis B, hepatitis B surface antigen positive, indicating that has been infected with the hepatitis B virus, if the course of the disease for more than six months, considered chronic hepatitis B, such patients vaccination is useless, according to the patient’s condition to determine whether antiviral treatment.