Widening of the incisor spacing is one of the symptoms of mannoside storage disease type II. Diagnosis is made on the basis of clinical symptoms, X-ray manifestations, recurrent infections, mental retardation, motor retardation, biopsy of liver and other tissues showing deficiency of acid-type alpha-mannosidase and absence of excessive mucopolysaccharide excretion in the urine. Peripheral blood picture: vacuoles are seen in neutrophils lymphocytes and bone marrow cells biopsy biochemical analysis of liver and other tissues show increased mannoside and acid type alpha-mannosidase deficiency oligosaccharides containing mannose in the urine. X-ray manifestations: for mild multiple osteogenesis imperfecta lumbar vertebral body hypoplasia in the shape of a bird’s beak iliac wing mild ectopia hip ectopia deformity widening of ribs epiphyseal diaphysis of the long bones metacarpal and phalangeal thickening of the cranial vault and cranial vault and skull base sclerosis in some cases may be present in severe scoliosis and hunchback. Mannoside Storage Disease Type II mostly develops after 2 years of age, with normal physical and psychomotor development, and progressive cerebral developmental delay starting after 2 years of age, frequent respiratory infections, ugly face, thick and thick eyebrows, wider spacing between incisors, bulging jaws, low anterior hairline, and mild bilateral deafness (most of which is sensory). Some patients may have allodynia.