The difference between perianal fungal infection and eczema is mainly due to different triggering causes, different clinical manifestations, different examination results and different treatment modalities. 1. Different triggering causes: perianal fungal infection is a skin disease caused by fungal infection, which can occur around the anus. Perianal eczema, on the other hand, is related to a variety of internal and external factors, such as allergies, heredity and so on. 2. Clinical manifestations are different: fungal infection rarely occurs around the anus, may lead to localized ring-shaped erythema, pigmentation, itching is generally not intense. Perianal eczema symptoms are limited to the skin around the anus, sometimes involving the perineum, mainly manifested as localized redness, swelling, vesicles, oozing, itching. 3. Different examination results: It is recommended to go to the hospital dermatology department for examination, fungal microscopy to see mycelium or spores, can be determined to be caused by fungal infection. If no mycelium or spores are found, it can also be considered related to perianal eczema. 4. Different treatment: perianal fungal infection, can be given antifungal drugs, such as ketoconazole ointment, bifonazole spray, etc., have the effect of inhibiting or killing fungi. For perianal eczema, tacrolimus ointment and pimecrolimus cream can be given, together with oral loratadine, levocetirizine hydrochloride, olopatadine hydrochloride and other medications if necessary, to help relieve itching. In summary, there is a clear difference between perianal fungal infection and perianal eczema. It is recommended to go to the dermatology department of the hospital for examination and follow the doctor’s instructions to clarify the diagnosis.