The most popular cosmetic wrinkle reduction procedure in the 21st century – Botulinum toxin type A injections. With the continuous research, Botulinum toxin type A is widely used in many fields such as ophthalmology, neurology, orthopedics and plastic and cosmetic surgery. 1.Used for facial and neck wrinkle removal: forehead lines, frown lines, crow’s feet, nasal dorsal transverse lines, nasal small column transverse lines, cheek folds, perioral radiating lines, broad neck lines, etc. 2.Improve contour and dynamic beauty: correction of simple bite muscle hypertrophy, nasal deformity, improvement of nasolabial folds, drooping corners of the mouth, improvement of gingival smile, jaw crease and calf contour (thin calf), etc. 3.Treatment of glandular diseases and trauma: such as treatment of hyperhidrosis, salivation, salivary fistula, salpingitis, alligator tear syndrome, nasal mucosa degenerative diseases, etc. 4.Treatment of head and neck dystonia: such as idiopathic blepharospasm, facial muscle twitching disorder, spastic slant neck, asymmetric deformity after facial palsy, etc. 5.Use in cosmetic ophthalmology: such as improving eyebrow shape, correcting eyelid and lid deformity, treating strabismus and amblyopia, nystagmus and thyroid-related ophthalmopathy, etc. 6.Extended application: adjuvant treatment after cosmetic surgery (laser wrinkle removal, soft tissue filling) for scarring and obesity, night grinding, pain and pruritus, skin vasomotor dysfunction, vulvar odor, etc.