Oral acromegaly can be detected using nucleic acid testing as an auxiliary means of examination, including fluorescent real-time PCR, hybridization capture 2 generation technology, etc., as follows. 1. Fluorescent real-time PCR: fluorescent groups are added to the PCR reaction system, based on multiplex fluorescent PCR technology, real-time monitoring of the accumulation of fluorescent signals. Fluorescent real-time PCR can detect 15 HPV subtypes and distinguish their specific types, which is simple and time-consuming. 2. Hybridization capture 2-generation technology: using the amplification of antibody capture signal and chemiluminescence signal detection, simultaneous detection of 13 hrHPV and the corresponding viral load, simple and easy to implement, the test results are more objective. It is recommended to go to a regular medical institution to receive professional treatment.