Panic palpitations caused by physiological factors do not need to use drugs, disease factors caused by the general can take beta-blockers such as metoprolol, bisoprolol. High blood pressure in the middle of the night can take antihypertensive drugs such as nifedipine extended-release tablets. I. Physiological factors: such as strenuous exercise, mental stress, and drinking coffee, may lead to panic palpitations in the middle of the night high blood pressure, to rule out these factors, it can be returned to normal. II. Pathological factors 1. β-blockers: such as propranolol, metoprolol, bisoprolol. β-blockers are a type of drug that can selectively bind to β-adrenergic receptors, thus antagonizing the agonistic effect of neurotransmitters and catecholamines on β-receptors. Propranolol is used for the treatment of arrhythmias due to various reasons, such as atrial and ventricular premature beats, sinus and supraventricular tachycardia, atrial fibrillation, etc. 2. Nifedipine extended-release tablets: it is a dihydropyridine calcium antagonist used for the prevention and treatment of angina pectoris in coronary artery disease, and is also suitable for various types of hypertension, and also has good efficacy in persistent and severe hypertension. The efficacy is superior to that of beta receptor antagonists. Nifedipine blocks calcium channels to diastole vascular smooth muscle, better efficacy, suitable for long-term use. The above drugs should be used in a standardized manner under the guidance of a physician, if the symptoms are more serious or accompanied by other obvious symptoms, it is recommended to go to the hospital for examination and standardized treatment. Do not blindly use drugs.