The prevalence of cervical human papillomavirus (HPV) infection is high, ranging from 4% to 20% in normal individuals, and the probability of lifelong cumulative infection can be as high as 60% to 70%. Cervical diseases associated with HPV include: cervical acromegaly, cervicitis, cervical precancer (also known as cervical intraepithelial neoplasia, CIN) and cervical cancer. Low-risk HPV infection mainly causes cervical warts and non-specific inflammation of the cervix (cervical erosion), while high-risk infection is the main causative factor for CIN and cervical cancer. According to statistics, the infection rate of HPV is 70%-78% in CIN1, 80%-89% in CIN2 or CIN3, and up to 99% in cervical cancer. Cervical cancer is a common malignant tumor of female reproductive system, ranking second in female malignant tumors. The incidence and mortality rate of cervical cancer in China accounts for 1/3 of the world, and the incidence rate of cervical cancer is now significantly younger, with a significant increase in the incidence rate of cervical cancer in women under 35 years old. Since there is a long time interval between HPV infection and precancerous lesions, and between precancerous lesions and the onset of cervical cancer, timely and effective treatment of cervical-related diseases with HPV infection is of great significance to effectively control the occurrence of cervical cancer. Traditional treatment of cervical warts and cervical erosion mainly uses freezing, electrocautery, CO2 laser, microwave, and topical caustic drugs, but the efficacy is not satisfactory, and the recurrence rate of warts has been reported to be as high as 56%. The cervical vessels are rich, the warts are brittle and extensive, they bleed easily, the depth is difficult to control, and there is subclinical infection, so it is often not effective and complete removal of warts, and the recurrence rate is high after treatment. In addition, it can easily lead to cervical canal stenosis and infertility, so it is not the ideal treatment for cervical warts and cervical erosion. The current treatment for CIN mainly involves destruction or removal of the cervical lesion area by electrocautery or laser, or if more aggressive, local cone excision of the cervix. The problems with these treatments are that they are prone to miscarriage in pregnancy; reduction of cervical mucus due to removal of the cervical gland, which may produce infertility; and difficulties in postoperative examination. Since cervical HPV infection-related diseases mostly occur in unmarried or unborn women, it is imperative to establish treatments with high safety, few side effects, effectiveness, and low recurrence rates. 5-Aminoketoglutaric acid photodynamic (ALA-PDT) technology is a new minimally invasive, actively targeted treatment based on the interaction of light, photosensitizers and oxygen. 5-aminoketoglutaric acid (ALA) is a photosensitizer that dynamically concentrates in proliferating abnormal, actively growing tissue cells. Under certain wavelengths of light, monomorphic oxygen is produced as a result of photosensitization of the ingested drug, leading to photo-oxidative inactivation of biological macromolecules, which causes organelle damage and destruction of the target tissue for therapeutic purposes. (infiltration depth is within 3mm). No damage to normal tissue cells. The photosensitizer has high target tissue selectivity and can rapidly reach the highest concentration in the target tissue, with little toxic side effects and high safety. The drug component is a single compound rather than a mixture, and the clearance time in the body is short. At the same time, it is popular among patients because it can be administered locally, the method is simple and easy to operate, the recurrence rate is extremely low, and the treatment can be repeated. At present, this technology is mainly used for the treatment of tumors, precancerous lesions and diseases caused by human papilloma virus (HIV) infection. The Department of Dermatology of the First Hospital of Jilin University has recently launched the treatment of HPV-related cervical diseases with ALA-PDT, the advantages of which are: 1. local drug application, less trauma, less systemic side effects, photodynamic therapy with the help of fiber optics and other interventional technologies, avoiding the trauma and pain caused by surgery; 2. fast intracellular metabolism, no accumulation, no special avoidance of light; 3. targeted treatment, good selectivity, directly hitting the lesions in the light area. It is the best choice for patients who are old and weak and cannot tolerate surgery; 6. Thus, the recurrence rate can be reduced. According to clinical statistics, the HPV clearance rate is 80% after 3 months of photodynamic therapy for HPV subclinical infection, and the recurrence rate is 5% after one year of follow-up.