(Disclaimer: This article is for scientific use only, and the information in the following content has been processed to protect patient privacy) Abstract: The patient, a 63-year-old male, developed blisters all over his body several months ago, and had visited several hospitals and was diagnosed with common aspergillosis, but his condition was not well controlled, so he came to our department. After examination, it was clear that the patient’s rash was extensive and serious, and required hospitalization. After hospitalization and standardized medication, the patient’s condition gradually improved, and after discharge, he continued to use medication, and his condition was controlled and stable without recurrence. The patient was discharged from the hospital with continuous medication. In recent months, blisters appeared on her body, with a foul odor and severe itching at the ruptured areas. After examining the patient’s condition, we found that he had extensive blisters all over his body, many of which had broken down and appeared as vesicles, and there was a foul odor when he took off his clothes. After admission, the patient was given sodium methylprednisolone succinate for injection and ceftriaxone sodium for injection, but after 1 week of treatment, the condition was not well controlled, and new blisters still occurred every day, and the patient himself was in pain and agitation. Considering that the patient’s condition was relatively serious, the patient was advised to use human blood gammaglobulin shock therapy and increase the dose of injectable methylprednisolone sodium succinate. After adjusting the treatment plan for 3 days, the patient’s condition improved significantly, no more new blisters appeared, the existing blisters dried and crusted, and the itching symptoms were significantly relieved. III. Treatment effect After 14 days of hospitalization and careful care, the blisters on the patient’s body dried, crusted and fell off, there were no new blisters, and there was no more odor, and the itching symptoms were significantly reduced. However, common aspergillosis is prone to recurrence, and maintenance treatment with medication is still required after the blisters subside, with gradual reduction, so the patient was allowed to come to the outpatient clinic for a review every 15 days after discharge. During the 6-month outpatient follow-up, the patient was highly compliant, took the medication on time, and had stable disease control with no recurrence. After 14 days of inpatient treatment and 6 months of outpatient follow-up, the patient’s condition was under control, and as a doctor, I was very pleased. However, the disease is prone to recurrence, and patients also need to pay attention to the following matters in their future lives: 1. Common aspergillosis has a lot to do with personal immune factors, and it is very important to adjust the physical state and immunity, so you can exercise properly, but not to be fatigued, not to stay up late, and to go to sleep before 10:00 p.m.; 2. Patients also need to adjust their emotions, not to give themselves too much pressure, and not to be anxious; 3. Avoid drinking alcohol and not to eat 4, the disease is an autoimmune disease, can not be cured, need long-term drug maintenance to reduce recurrence, to be stable after the drug can gradually reduce the amount, never stop the drug without authorization, otherwise it is easy to cause a relapse of the disease. During the period of medication, the blood indexes should be reviewed regularly to monitor the side effects of medication. After the disease is stabilized, it still needs to be maintained with medication (mainly glucocorticoids and immunosuppressants) and gradually reduced according to the disease, which is a slow process that takes years in some cases. In the outpatient clinic, we have encountered several cases of patients who discontinued their medications without following the doctor’s orders, resulting in relapse and hospitalization, which increased both pain and cost.