Artificial joint replacement can restore movement to stiff joints and eliminate pain. However, diabetic patients are prone to complications such as infection and prosthesis loosening after artificial joint replacement. In recent years, we have successfully performed artificial joint replacement in diabetic patients without serious cardiac, renal and peripheral vascular complications, after thorough and correct perioperative management and good glucose control and other medical treatments. In our follow-up of dozens of patients for 1 to 3 years, there was no recent postoperative wound infection and no late rate of deep infection. Therefore, we believe that diabetes mellitus is not a contraindication to artificial joint replacement surgery. For example, patient Chen, 72 years old, had diabetes mellitus for 7 years, had painful osteoarthritis in the left knee and could not walk, resumed walking after artificial knee replacement on September 22, 2003, and had good function at the follow-up after 2 years. Preoperative X-ray suggested osteoarthritis of the left knee, narrowing of the medial space, and significant osteophytes in the knee joint. Postoperative X-ray suggested good position of the prosthesis after left knee replacement, without loosening or dislocation.