Since the late 1980s, maggot therapy has re-emerged due to the proliferation of drug-resistant strains of bacteria. In the 21st century, as the population ages and chronic wounds such as diabetic foot disease and decubitus ulcers increase year by year, people need better treatments and maggot therapy is favored for its unique advantages. Currently, as antibiotics become more widely used, drug-resistant strains and multi-drug resistant super strains are increasing, while new antibiotics are developed at high cost and long lead time. In this race between humans and bacteria, we humans will not be able to achieve the final victory. Maggots, as creatures that existed on earth before dinosaurs, survive and reproduce in all corners of the world with their unique antibacterial effects, and will exist on this planet longer than we humans. With the development of new materials and technologies in the 21st century, many of the shortcomings of maggot therapy have been overcome, making it more convenient for people to use. For example, the bagged maggots invented by Europeans are very popular in Europe, and the maggot dressing with single, double, hinge-like structure invented by Monarch Labs in the United States has made the use of maggots more convenient and faster. There are at least 24 laboratories around the world that provide maggots for clinical use, and maggots are used in over 30 countries. Significant progress has also been made in the study of maggot secretions. As a Chinese nation that has made great contributions to human civilization and progress, it should have a place in the basic and clinical applications of maggot research and will certainly rise to the top. The future of maggot therapy, as a famous maggot therapy expert said: “This strange and bizarre treatment method has a fascinating history and will have a glorious and brilliant tomorrow.