It is recommended to interval at least 20 days for the second mole spotting. The color quality belongs to the pigment mass under the skin, and the effect of choosing to use carbon dioxide laser mole spotting is very good. After removing the pigmented mole with laser, local skin will appear cauterized lesions, and the second mole spotting can be performed only after the basic healing of the lesion surface. The skin metabolic cycle is 28 days, and the local burned surface needs about 20 days to recover on its own. When the local epidermis is not painful and itchy, and there are no infectious changes such as redness, swelling and pain, the second mole spotting can be performed. If the pigmented mole is too large, irregular in shape and uneven in color, it is recommended to choose surgical excision for more thorough removal, and pathological testing can be done. Do not choose laser mole spotting to prevent poor removal of pigmented mole from triggering degeneration of pigmented mole, which is detrimental to health.