The first line of medication for premature ejaculation is selective 5-hydroxytryptamine reuptake inhibitors such as dapoxetine. Selective 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine, are used to prolong ejaculation by blocking the reuptake of 5-hydroxytryptamine and increasing the concentration of 5-hydroxytryptamine in the central nervous system. Other drugs in this class include paroxetine and sertraline. This class of drugs is used to treat men between the ages of 18 and 64 who suffer from premature ejaculation. However, there are some adverse reactions to this class of drugs. The most common adverse reactions in clinical trials include headache, dizziness, nausea, diarrhea, insomnia, and fatigue. It should be noted that this drug should be contraindicated in patients who are allergic to this product, patients with significant cardiac pathology, and patients with moderate and severe liver injury. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences!