Chest tightness and shortness of breath, feeling breathless with a sense of pressure, may be caused by respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, pneumothorax, bronchiectasis, lung tumors, etc., but also due to cardiac diseases, such as coronary artery disease, arrhythmia, etc., but also due to mental illnesses, such as anxiety, etc., according to the conditions of the choice of medication or surgery for treatment. 1. Lung diseases: bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation need to follow the doctor’s prescription medication, such as terbutaline, budesonide, tiotropium bromide, hydrocortisone, levofloxacin, ceftriaxone, etc.; pneumothorax can be treated conservatively with internal medicine if the compression of the lungs is relatively small, and the lungs need to be operated if the compression is large; lung tumors should be operated as early as possible. 2. Heart disease: coronary heart disease can follow the doctor’s prescription oral aspirin enteric-coated tablets, atorvastatin, isosorbide mononitrate, danshen tablets, etc., if the condition worsens, it may need coronary artery angiography, and cardiac stent can be placed if necessary; arrhythmia can follow the doctor’s prescription oral metoprolol, bisoprolol, etc., and if it recurs and is accompanied by dizziness and other symptoms, it is necessary to have radiofrequency ablation surgical treatment. 3. Mental illness: some patients with mental anxiety, subjective chest tightness and shortness of breath, feeling out of breath with a sense of pressure, while the heart and lungs did not occur pathological changes, need to calm the emotions, if necessary, may need to comply with the doctor’s orders orally amitriptyline, haloperidol melittin tablets and so on. If the patient’s condition is recurring, it is recommended to go to the hospital as soon as possible to get a clear diagnosis and treatment according to the cause of the disease.