Hemorrhoids are the most common anal condition, and they include three types: internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids that have both internal and external hemorrhoids. Which hemorrhoid is the most serious cannot be answered simply by making a blanket statement and should depend on the specific condition of the patient. Both internal, external, and mixed hemorrhoids can be very mild or very severe. Internal hemorrhoids can even cause anemia and can be life-threatening if the symptoms of blood in the stool are very severe. External hemorrhoids, if symptomatic, can cause localized edema, inflammation, necrosis, and thrombosis in the patient’s anus, also affecting defecation and seriously affecting the patient’s quality of life. Mixed hemorrhoids, on the other hand, are both internal and external hemorrhoids, and circumferential mixed hemorrhoids are embedded, again a very serious condition in hemorrhoids.