Allergy triggering swollen lips is clinically known as angioedema of the lips, also known as giant urticaria. It mostly occurs in allergic patients, due to the loose tissue of the mouth and lips, after contact with allergens, small blood vessels under the lips dilate and permeability increases, causing a high degree of local edema, often accompanied by numbness, usually accompanied by certain triggers. 1, food factors: eating allergenic foods, such as fish, shellfish, peanuts, nuts, etc. It is generally recommended that patients undergo allergen testing and avoid eating allergenic foods again. 2, drug factors: some Patients are prone to allergy to drugs, such as penicillin, ibuprofen, aspirin, etc. In this case, allergic reactions need to stop taking drugs immediately; 3, inhalants: some patients will have allergic reactions to special substances, such as dust, pollen, animal dander, etc. Such patients are advised to wear masks to keep away from allergic substances; 4, physical factors: some patients are sensitive to temperature changes and prone to Allergic reactions, such as cold and heat stimulation, are recommended to keep the temperature as constant as possible and avoid large temperature differences. Patients can be treated symptomatically with antihistamines, such as cetirizine, loratadine, levocetirizine, etc., while staying away from allergens. The swelling subsides after 2-3 days or lasts longer and leaves no trace after subsiding. However, if the allergenic factors persist, it is easy to recur, so patients need to pay attention to avoid contact with allergens in general.