Smoker’s disease is a spontaneous unilateral or bilateral progressive occlusive disease of the terminal internal carotid arteries (distal to the siphon) and their major branches, in which a network of small vessels appears at the base of the brain, acting as a compensatory blood supply. Clinical manifestations: children: cerebral ischemia is the most common. Adult type: cerebral hemorrhage is the most common. Diagnosis: Whole brain angiography is the gold standard. Treatment: Cerebral blood flow reconstruction surgery.