At present, there is no drug that can make minor triple Yang completely turn negative, some patients after antiviral treatment, surface antigen can turn negative, but the probability is very low. First of all, minor triple positive refers to the positive of three of the five indicators of hepatitis B two-half, i.e. hepatitis B surface antigen, hepatitis B E antibody and hepatitis B core antibody. At present, there is no specific clinical drug that can make small triple positive turn negative. Hepatitis III patients should pay attention to maintain a regular daily routine, avoid drinking alcohol and maintain emotional stability. If there are indications for antiviral treatment, they can take entecavir, tenofovir and other medications as prescribed by the doctor or be treated by interferon injection. Standardized drug treatment can achieve clinical cure, that is, hepatitis B virus DNA negative, liver function is normal. However, it is difficult to make the minor triple yang turn negative, some patients may indeed turn negative, but the probability is very low.